Gain time in drawing and interpreting pedigrees linked to consanguineous marriages. PedigreeXP automatically calculates the coefficient of consanguinity and indicates it with a double-line.
Coefficient of consanguinity is the probability that a pair of alleles belonging to different individuals are the same, given their degree of common ancestry. Oxford Index
The offspring of consanguineous unions may be at increased risk to genetic disorders because of the expression of autosomal recessive gene mutations inherited from a common ancestor. The closer the biological relationship between parents, the greater is the probability that their offspring will inherit identical copies of one or more detrimental recessive mutations.
The coefficient of consanguinity is calculated and analysed to assist health professionals who provide genetic counseling and screening to related couples and their offspring.
It’s important for genetic counselors, geneticists or other health professionals to appropriately document and draw pedigrees of consanguineous marriages if present in the family.